Hi and welcome to my website!
I’m Daisy Shu, a postdoctoral research fellow in the Saint-Geniez Laboratory studying the role of metabolism and mitochondria in retinal eye disease at Schepens Eye Research Institute, Mass Eye and Ear, Harvard Medical School. I currently serve on the Association for Research in Vision and Ophthalmology (ARVO) Advocacy and Outreach Committee and the International Society for Eye Research Membership Committee. I was awarded the Ezell Fellow by the American Academy of Optometry Foundation in 2018. I am passionate about science communication and completed the ARVO SciComm Training Fellowship in 2017. Follow my scientific research journey via Instagram and Twitter.
I completed my PhD in 2019 at the Lens Research Laboratory under Frank Lovicu and John McAvoy at the University of Sydney. My PhD project explored the wound healing mechanisms in lens epithelial cells and the role of transforming growth factor-beta-induced epithelial-mesenchymal transition in cataract formation. By investigating the downstream signalling pathways mediating wound healing, I have discovered novel targets that can be blocked to specifically combat fibrotic cataract.
As multicellular organisms, maintaining the function of our cells involves coordinated cell-to-cell communication through signalling proteins. Using molecular biology techniques analysing protein and gene expression, my research seeks to eavesdrop on the cellular conversation mediating the wound healing response. To that end, I have collaborated on many projects exploring the the signaling pathways involved in wound healing mechanisms in different tissues of the eye:
- From January-March 2018, I collaborated on a project with Dr Andrew White and Dr Nicole Carnt at the Westmead Institute for Medical Research exploring the wound healing mechanisms following glaucoma filtration surgery. The most critical determinant of the success of glaucoma surgery is scar formation and by understanding the signalling pathways involved in scarring, novel anti-fibrotic agents can be developed to maximize the surgical success of glaucoma filtration surgery.
- From May-July 2018, I collaborated with Professor James Zieske at Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School under the supervision of Dr Xiaoqing Guo and Audrey Hutcheon on wound healing mechanisms in the cornea by exploring the interplay between TGF-beta and EGF signaling cascades.